Across TCGA pan-cancer cohorts, RNA5SP371 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RNA5SP371’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where RNA5SP371 RNA is repressed in tumor relative to normal tissue. In most cancer types RNA5SP371 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
THCA and LUSC are the cancer types where RNA5SP371 tumor–normal differential expression is most reproducible.