Across TCGA pan-cancer cohorts, RNA5SP23 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RNA5SP23’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where RNA5SP23 RNA is repressed in tumor relative to normal tissue. In most cancer types RNA5SP23 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

LUSC, LUAD, and PRAD are the cancer types where RNA5SP23 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNA5SP23 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	II,III,IV	−0.389	<.001	4	view →
LUAD	Female	All	−0.239	.005	3	view →
PRAD	All	All	+0.068	.025	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: RNA5SP23 RNA expression & survival · all RNA5SP23 data types