Across TCGA pan-cancer cohorts, RNA5SP226 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RNA5SP226’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RNA5SP226 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNA5SP226 is over-expressed in tumor, although a few such as UCEC and BRCA show the opposite, repressed pattern.

HNSC, UCEC, and COAD are the cancer types where RNA5SP226 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNA5SP226 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.145	.033	6	view →
UCEC	All	IV	−1.430	.031	2	view →
COAD	All	All	+0.561	.011	2	view →
BRCA	All	III,IV	−0.101	.039	2	view →
THCA	All	All	−0.086	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: RNA5SP226 RNA expression & survival · all RNA5SP226 data types