Across TCGA pan-cancer cohorts, RN7SL578P RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RN7SL578P’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RN7SL578P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RN7SL578P is over-expressed in tumor, although a few such as KIRP and BRCA show the opposite, repressed pattern.
HNSC, KIRP, and BRCA are the cancer types where RN7SL578P tumor–normal differential expression is most reproducible.