Q-omics provides the consensus-scored RN7SL459P profile across patient tissues and cancer cell-line models. RN7SL459P expression is associated with patient survival in 16 of 34 cancer types, with the highest sampling consensus in MESO. Among the 18 cancer types available for tumor–normal comparison, RN7SL459P is differentially expressed in 3, with the highest sampling consensus in HNSC. Additionally, RN7SL459P RNA expression shows 6,555 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight MESO, HNSC, and LSCC as cancer lineages where RN7SL459P shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for RN7SL459P — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes RN7SL459P survival associations across molecular data types. RN7SL459P RNA expression shows survival associations in the most cancer types (16). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible RN7SL459P RNA expression–survival associations across cancer types. High RN7SL459P expression shows unfavorable associations in MESO, ACC, HNSC and THCA, but favorable associations in KIRP and ESCA. The MESO Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify MESO as the clearest survival context for RN7SL459P RNA expression.
This table summarizes RN7SL459P tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 3. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for RN7SL459P. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. RN7SL459P shows lower tumor expression in HNSC and THCA and higher tumor expression in KIRP. The HNSC box plot shows higher RN7SL459P RNA expression in normal versus tumor tissue (log2 FC = −0.069, t-test p = .007).
This table shows molecular features associated with RN7SL459P in patient tissues and cancer cell lines. In patient samples, RN7SL459P shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set.
