Across TCGA pan-cancer cohorts, RN7SL443P RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RN7SL443P’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where RN7SL443P RNA is repressed in tumor relative to normal tissue. In most cancer types RN7SL443P is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.
LUSC and KIRC are the cancer types where RN7SL443P tumor–normal differential expression is most reproducible.