Across TCGA pan-cancer cohorts, RN7SKP9 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RN7SKP9’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where RN7SKP9 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RN7SKP9 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
LUSC, HNSC, and THCA are the cancer types where RN7SKP9 tumor–normal differential expression is most reproducible.