Across TCGA pan-cancer cohorts, RN7SKP75 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RN7SKP75’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where RN7SKP75 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RN7SKP75 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.
KICH and LUSC are the cancer types where RN7SKP75 tumor–normal differential expression is most reproducible.