Across TCGA pan-cancer cohorts, RN7SKP4 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of RN7SKP4’s most consistent transcriptional readouts.
The strongest signal is observed in stomach adenocarcinoma (STAD), where RN7SKP4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RN7SKP4 is over-expressed in tumor, although a few such as HNSC and THCA show the opposite, repressed pattern.
STAD, HNSC, and COAD are the cancer types where RN7SKP4 tumor–normal differential expression is most reproducible.