Across TCGA pan-cancer cohorts, RN7SKP261 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RN7SKP261’s most consistent transcriptional readouts.
The strongest signal is observed in bladder urothelial carcinoma (BLCA), where RN7SKP261 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RN7SKP261 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.
BLCA, LUAD, and LUSC are the cancer types where RN7SKP261 tumor–normal differential expression is most reproducible.