Across TCGA pan-cancer cohorts, RN7SKP253 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RN7SKP253’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where RN7SKP253 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RN7SKP253 is over-expressed in tumor, although a few such as KIRP show the opposite, repressed pattern.
THCA and KIRP are the cancer types where RN7SKP253 tumor–normal differential expression is most reproducible.