Across TCGA pan-cancer cohorts, RN7SKP219 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RN7SKP219’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where RN7SKP219 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RN7SKP219 is over-expressed in tumor, although a few such as KIRP show the opposite, repressed pattern.
BRCA and KIRP are the cancer types where RN7SKP219 tumor–normal differential expression is most reproducible.