Across TCGA pan-cancer cohorts, RN7SKP21 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RN7SKP21’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where RN7SKP21 RNA is repressed in tumor relative to normal tissue. In most cancer types RN7SKP21 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.
LUSC and THCA are the cancer types where RN7SKP21 tumor–normal differential expression is most reproducible.