Across TCGA pan-cancer cohorts, RN7SKP185 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RN7SKP185’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where RN7SKP185 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RN7SKP185 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
KIRP and THCA are the cancer types where RN7SKP185 tumor–normal differential expression is most reproducible.