Across TCGA pan-cancer cohorts, RN7SKP146 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RN7SKP146’s most consistent transcriptional readouts.
The strongest signal is observed in bladder urothelial carcinoma (BLCA), where RN7SKP146 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RN7SKP146 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
BLCA and THCA are the cancer types where RN7SKP146 tumor–normal differential expression is most reproducible.