RMI2

Across TCGA cell cohorts, RMI2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,008 significant associations in total. BONE shows the largest number of these associations.

The most reproducible RMI2-associated GO terms across cancer lineages are Negative regulation of double-strand break repair via homologous recombination, Mitotic DNA replication, and Resolution of DNA recombination intermediates. Each is linked with RMI2 in more than 16 cancer types. Because this analysis shows association rather than direction, both RMI2-to-partner and partner-to-RMI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of double-strand break repair via homologous recombination grouped by RMI2-low versus RMI2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RMI2→partner) and Y-score (partner→RMI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of double-strand break repair via homologous recombination →	+0.104	+1.072	<.001	<.001	3	17
BONE	Mitotic DNA replication →	+0.226	+1.192	.002	.001	3	15
BONE	Resolution of DNA recombination intermediates →	+0.183	+1.281	.002	<.001	3	15
SOFT_TISSUE	Cell cycle DNA replication initiation →	+0.186	+1.120	<.001	.001	3	15
SOFT_TISSUE	Nuclear cell cycle DNA replication initiation →	+0.186	+1.120	<.001	.001	3	15
SOFT_TISSUE	Mitotic DNA replication initiation →	+0.186	+1.120	<.001	.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,008 associations by consensus.

Negative regulation of double-strand break repair via homologous recombination by RMI2 expression — BONE

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