RMDN2

Across TCGA pan-cancer cohorts, RMDN2 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of RMDN2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where RMDN2 RNA is repressed in tumor relative to normal tissue. In most cancer types RMDN2 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, KICH, and LUAD are the cancer types where RMDN2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RMDN2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−1.754	<.001	12	view →
KICH	Female	II,III,IV	−1.718	<.001	11	view →
LUAD	All	III,IV	−1.051	<.001	9	view →
LUSC	Male	III,IV	−2.037	<.001	8	view →
READ	All	All	−1.371	<.001	7	view →
BLCA	Male	All	−0.345	.010	7	view →
UCEC	All	All	−0.895	<.001	6	view →
KIRP	Male	All	−0.591	<.001	6	view →
BRCA	All	III,IV	−0.561	<.001	6	view →
KIRC	All	All	−0.172	.017	4	view →
STAD	All	All	−0.406	.003	3	view →
CHOL	All	All	−0.883	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

RMDN2–COAD

Open the COAD breakdown →