RMC1

Across TCGA patient cohorts, RMC1 mutation is significantly associated with the RNA expression of many other genes, with 2,625 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RMC1-associated genes across cancer lineages are RNU1-18P, H2AZ1, and TIPIN. Each is linked with RMC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RMC1-to-partner and partner-to-RMC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-18P grouped by RMC1-low versus RMC1-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RMC1→partner) and Y-score (partner→RMC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	RNU1-18P →	+0.472	+5.355	<.001	.005	3	3
UCEC	H2AZ1 →	+0.538	+2.238	.002	.006	3	3
UCEC	TIPIN →	+0.582	+2.960	<.001	<.001	3	3
UCEC	FDFT1 →	+0.540	+2.102	.001	.001	3	3
COAD	THAP5P1 →	+0.393	+3.483	.007	.004	3	3
UCEC	KIF2C →	+0.733	+2.081	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,625 associations by consensus.

RNU1-18P by RMC1 expression — LIHC

Explore this box plot interactively →