RMC1

Across TCGA patient cohorts, RMC1 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RMC1-associated genes across cancer lineages are INPP4B, PCNA, and CDK1. Each is linked with RMC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RMC1-to-partner and partner-to-RMC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by RMC1-low versus RMC1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RMC1→partner) and Y-score (partner→RMC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	INPP4B →	-0.628	-3.000	<.001	.034	3	2
COAD	PCNA →	+0.322	+2.820	.008	.035	3	2
COAD	CDK1 →	+0.322	+3.178	<.001	.010	3	2
UCEC	Cyclin-E1 →	+0.361	+1.415	.027	.046	3	2
UCEC	FASN →	+0.346	+1.415	.019	.046	3	2
UCEC	ASNS →	+0.493	+1.765	<.001	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

INPP4B by RMC1 expression — COAD

Explore this box plot interactively →