RMC1

Across TCGA cell cohorts, RMC1 mutation is significantly associated with the mutation status of many other genes, with 1,635 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RMC1-associated genes across cancer lineages are PNPLA6, CTU1, and ANXA4. Each is linked with RMC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RMC1-to-partner and partner-to-RMC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PNPLA6 grouped by RMC1-low versus RMC1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RMC1→partner) and Y-score (partner→RMC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PNPLA6 →	+2.779	+4.326	.006	.006	1	3
BLOOD_Leukemia	CTU1 →	+4.894	+4.894	.004	.004	1	3
BLOOD_Leukemia	ANXA4 →	+5.894	+5.321	.002	.002	1	3
LARGE_INTESTINE	HLA-E →	+4.799	+3.672	.002	.002	1	3
BLOOD_Leukemia	INTS11 →	+4.309	+4.560	.007	.007	1	3
BLOOD_Leukemia	HRC →	+3.894	+5.247	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,635 associations by consensus.

PNPLA6 by RMC1 expression — BLOOD_Leukemia

Explore this box plot interactively →