RLN2

Across TCGA patient cohorts, RLN2 mutation is significantly associated with the RNA expression of many other genes, with 275 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RLN2-associated genes across cancer lineages are MIR521-2, RNA5SP70, and RN7SL196P. Each is linked with RLN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RLN2-to-partner and partner-to-RLN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR521-2 grouped by RLN2-low versus RLN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RLN2→partner) and Y-score (partner→RLN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR521-2 →	+0.266	+3.069	.001	.009	3	2
UCEC	RNA5SP70 →	+0.255	+4.300	<.001	.005	3	2
BRCA	RN7SL196P →	+0.159	+7.731	<.001	.009	3	1
UCEC	CD8A →	+1.965	+3.343	<.001	.005	3	1
UCEC	GBP5 →	+2.092	+3.332	<.001	.005	3	1
UCEC	MRPL17 →	+0.468	+3.343	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 275 associations by consensus.

MIR521-2 by RLN2 expression — UCEC

Explore this box plot interactively →