RLN2

Across TCGA patient cohorts, RLN2 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RLN2-associated genes across cancer lineages are ERK2, FOXO3a_pS318_S321, and MEK1. Each is linked with RLN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RLN2-to-partner and partner-to-RLN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by RLN2-low versus RLN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RLN2→partner) and Y-score (partner→RLN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.232	+3.169	.028	.020	3	1
UCEC	FOXO3a_pS318_S321 →	-0.157	-3.169	.021	.020	3	1
UCEC	MEK1 →	+0.421	+3.169	.036	.020	3	1
UCEC	TFRC →	+0.844	+3.000	.003	.036	3	1
UCEC	4E-BP1_pT37_T46 →	-0.487	-3.169	.018	.020	3	1
UCEC	Caspase-7-cleavedD198 →	+1.139	+3.169	<.001	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

ERK2 by RLN2 expression — UCEC

Explore this box plot interactively →