RLN2

Across TCGA cell cohorts, RLN2 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RLN2-associated genes across cancer lineages are FCN2, PNPLA5, and DEFB108B. Each is linked with RLN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RLN2-to-partner and partner-to-RLN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FCN2 grouped by RLN2-low versus RLN2-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RLN2→partner) and Y-score (partner→RLN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	FCN2 →	+0.033	+5.087	<.001	.004	3	1
BLOOD_Leukemia	PNPLA5 →	+0.016	+4.409	.009	.005	3	1
BLOOD_Leukemia	DEFB108B →	+0.161	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	OR10T2 →	+1.035	+4.276	<.001	.007	3	1
BLOOD_Leukemia	OR10R2 →	+2.141	+4.551	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

FCN2 by RLN2 expression — URINARY_TRACT

Explore this box plot interactively →