RLF

Across TCGA pan-cancer cohorts, RLF Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RLF data layer compared with 23 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher RLF Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated RLF expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

UCEC, KIRP, and PRAD are the cancer types where RLF Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.941	0.429	.008	34	view →
KIRP	OS	Median	All	0.111	0.702	.001	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
SKCM	OS	Median	IV	0.415	0.861	.014	6	view →
LUSC	DFS	Median	All	0.807	0.383	.040	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RLF–UCEC (DFS)

Open the UCEC breakdown →