RLF

Across TCGA pan-cancer cohorts, RLF mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated RLF data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher RLF mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated RLF expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

LSCC, HNSC, and LUAD are the cancer types where RLF mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	II,III,IV	1.000	0.734	<.001	43	view →
HNSC	DFS	Quartile	II,III,IV	1.000	0.841	.004	8	view →
LUAD	OS	Quartile	All	0.973	0.788	.021	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

RLF–LSCC (OS)

Open the LSCC breakdown →