RLF

Across TCGA patient cohorts, RLF mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RLF-associated genes across cancer lineages are 14-3-3_epsilon, 14-3-3_beta, and mTOR_pS2448. Each is linked with RLF in more than 2 cancer types. Because this analysis shows association rather than direction, both RLF-to-partner and partner-to-RLF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_epsilon grouped by RLF-low versus RLF-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RLF→partner) and Y-score (partner→RLF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	14-3-3_epsilon →	+0.180	+3.042	.007	.018	3	3
UCEC	14-3-3_beta →	-0.078	-1.973	.006	.008	3	2
UCEC	mTOR_pS2448 →	-0.103	-1.986	.014	.002	3	2
UCEC	PCNA →	+0.232	+2.000	<.001	<.001	3	2
UCEC	PDCD4 →	-0.284	-1.415	.034	.040	3	2
UCEC	Annexin-1 →	+0.566	+2.321	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

14-3-3_epsilon by RLF expression — COAD

Explore this box plot interactively →