RLF

Across TCGA cell cohorts, RLF RNA expression is significantly associated with the go_rna of many other GO terms, with 3,634 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RLF-associated GO terms across cancer lineages are Protein modification by small protein removal, Sex-chromosome dosage compensation, and Positive regulation of organelle assembly. Each is linked with RLF in more than 15 cancer types. Because this analysis shows association rather than direction, both RLF-to-partner and partner-to-RLF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein modification by small protein removal grouped by RLF-low versus RLF-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RLF→partner) and Y-score (partner→RLF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Protein modification by small protein removal →	+0.049	+0.494	<.001	.001	3	16
OVARY	Sex-chromosome dosage compensation →	+0.083	+0.730	.004	.002	3	15
STOMACH	Positive regulation of organelle assembly →	+0.064	+0.856	<.001	.003	2	16
URINARY_TRACT	Dosage compensation by inactivation of X chromosome →	+0.102	+0.981	.002	.008	3	14
UPPER_AERODIGESTIVE_TRACT	Heterochromatin organization →	+0.053	+0.673	<.001	.005	3	14
SOFT_TISSUE	Termination of RNA polymerase II transcription →	+0.162	+0.752	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,634 associations by consensus.

Protein modification by small protein removal by RLF expression — SOFT_TISSUE

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