RLF

Across TCGA cell cohorts, RLF mutation is significantly associated with the RNA expression of many other genes, with 276 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RLF-associated genes across cancer lineages are NAT8B, PLA2G3, and C20orf85. Each is linked with RLF in more than 1 cancer types. Because this analysis shows association rather than direction, both RLF-to-partner and partner-to-RLF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NAT8B grouped by RLF-low versus RLF-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RLF→partner) and Y-score (partner→RLF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NAT8B →	+0.105	+3.113	<.001	.004	3	2
LARGE_INTESTINE	PLA2G3 →	+1.172	+3.347	<.001	.005	3	2
SOFT_TISSUE	C20orf85 →	+0.086	+4.369	<.001	.008	3	1
SOFT_TISSUE	OR1L4 →	+0.053	+4.369	<.001	.008	3	1
SOFT_TISSUE	OR4D6 →	+0.035	+4.977	<.001	.002	3	1
SOFT_TISSUE	OR51L1 →	+0.027	+4.369	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 276 associations by consensus.

NAT8B by RLF expression — SKIN

Explore this box plot interactively →