RLBP1

Across TCGA cell cohorts, RLBP1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RLBP1-associated genes across cancer lineages are WFDC11, C20orf173, and DEFA4. Each is linked with RLBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RLBP1-to-partner and partner-to-RLBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WFDC11 grouped by RLBP1-low versus RLBP1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RLBP1→partner) and Y-score (partner→RLBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	WFDC11 →	+0.088	+4.209	<.001	.006	3	1
LARGE_INTESTINE	C20orf173 →	+0.025	+3.684	<.001	.006	3	1
LARGE_INTESTINE	DEFA4 →	+0.032	+4.437	<.001	.004	3	1
LARGE_INTESTINE	OR2Z1 →	+0.012	+4.437	<.001	.004	3	1
LARGE_INTESTINE	ODF4 →	+0.018	+4.437	<.001	.004	3	1
LARGE_INTESTINE	CACNG3 →	+0.005	+4.217	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

WFDC11 by RLBP1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →