RIT2

Across TCGA patient cohorts, RIT2 protein abundance is significantly associated with the RNA expression of many other genes, with 2,518 significant associations in total. GBM shows the largest number of these associations.

The most reproducible RIT2-associated genes across cancer lineages are SEZ6L, SEPTIN3, and KCNK10. Each is linked with RIT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RIT2-to-partner and partner-to-RIT2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RIT2 versus SEZ6L in GBM, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIT2→partner) and Y-score (partner→RIT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SEZ6L →	+1.955	+0.840	<.001	<.001	3	1
GBM	SEPTIN3 →	+0.936	+0.473	<.001	.005	3	1
GBM	KCNK10 →	+0.852	+0.702	<.001	<.001	3	1
GBM	SPRTN →	+0.316	+0.660	<.001	<.001	3	1
GBM	CPNE6 →	+0.892	+0.675	<.001	.001	3	1
GBM	NFKBIA →	-0.696	-0.662	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,518 associations by consensus.

RIT2 vs SEZ6L — GBM

Explore this scatter interactively →