RIT2

Across TCGA cell cohorts, RIT2 RNA expression is significantly associated with the go_rna of many other GO terms, with 420 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible RIT2-associated GO terms across cancer lineages are Positive regulation of smooth muscle cell differentiation, Negative regulation of Notch signaling pathway, and Response to odorant. Each is linked with RIT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both RIT2-to-partner and partner-to-RIT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of smooth muscle cell differentiation grouped by RIT2-low versus RIT2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RIT2→partner) and Y-score (partner→RIT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of smooth muscle cell differentiation →	-0.120	-1.066	.003	.006	3	3
BREAST	Negative regulation of Notch signaling pathway →	+0.089	+0.037	<.001	.001	3	3
LUNG_SCLC	Response to odorant →	-1.185	-0.994	<.001	.007	3	2
LUNG_SCLC	Microtubule-based transport →	+0.061	+0.689	.001	.001	3	2
BREAST	Zinc ion transport →	-0.082	-0.043	<.001	.002	3	2
BREAST	Leukocyte aggregation →	-0.342	-0.026	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 420 associations by consensus.

Positive regulation of smooth muscle cell differentiation by RIT2 expression — LUNG_SCLC

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