RIT2

Across TCGA cell cohorts, RIT2 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RIT2-associated genes across cancer lineages are OC90, SLC7A14, and SSMEM1. Each is linked with RIT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RIT2-to-partner and partner-to-RIT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OC90 grouped by RIT2-low versus RIT2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIT2→partner) and Y-score (partner→RIT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OC90 →	+0.013	+5.201	<.001	.006	3	2
BLOOD_Myeloma	SLC7A14 →	+0.019	+3.285	.004	.009	3	1
LARGE_INTESTINE	SSMEM1 →	+0.023	+3.707	.008	.009	3	1
LARGE_INTESTINE	ELOA3DP →	+0.037	+4.688	<.001	<.001	3	1
LUNG_NSCLC_LUAD	CXorf51A →	+0.048	+4.887	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

OC90 by RIT2 expression — BLOOD_Leukemia

Explore this box plot interactively →