Across TCGA patient cohorts, RIPPLY3 protein abundance is significantly associated with the RNA expression of many other genes, with 34 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible RIPPLY3-associated genes across cancer lineages are LIN7A, KRR1, and YEATS4. Each is linked with RIPPLY3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RIPPLY3-to-partner and partner-to-RIPPLY3 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIPPLY3→partner) and Y-score (partner→RIPPLY3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LIN7A →	+2.166	+1.660	.001	.005	3	1
BRCA	KRR1 →	+0.515	+0.910	<.001	<.001	3	1
BRCA	YEATS4 →	+0.780	+1.000	.006	.001	3	1
BRCA	COG6 →	+0.633	+0.957	.007	<.001	3	1
BRCA	RALBP1 →	+0.611	+1.246	<.001	<.001	3	1
BRCA	LNP1 →	-0.893	-0.814	.008	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Exploration

RIPPLY3 survival (RNA) · tumor vs normal (RNA) · all RIPPLY3 data types