RIPPLY1

Across TCGA pan-cancer cohorts, RIPPLY1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RIPPLY1 data layer compared with 30 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher RIPPLY1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated RIPPLY1 expression acts as an unfavorable survival marker.

COAD, HNSC, and LUSC are the cancer types where RIPPLY1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.103	0.801	<.001	24	view →
HNSC	OS	Median	IV	0.002	0.734	<.001	12	view →
LUSC	OS	Median	All	0.192	0.724	.040	6	view →
SKCM	DFS	Median	All	0.209	0.728	.020	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RIPPLY1–COAD (OS)

Open the COAD breakdown →