Across TCGA patient cohorts, RIPK4 mutation is significantly associated with the RNA expression of many other genes, with 2,390 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible RIPK4-associated genes across cancer lineages are RWDD3, DONSON, and ZBTB8OS. Each is linked with RIPK4 in more than 2 cancer types. Because this analysis shows association rather than direction, both RIPK4-to-partner and partner-to-RIPK4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIPK4→partner) and Y-score (partner→RIPK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RWDD3 →	+0.622	+2.434	<.001	.001	3	3
UCEC	DONSON →	+0.526	+3.708	.001	<.001	3	3
SKCM	ZBTB8OS →	+0.522	+1.925	<.001	.009	3	3
COAD	ZNF232-AS1 →	+0.562	+3.237	<.001	.009	3	3
SKCM	MRPS18C →	+0.302	+3.373	.004	.004	3	3
UCEC	RBBP8 →	+0.657	+2.087	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,390 associations by consensus.

Exploration

RIPK4 survival (RNA) · tumor vs normal (RNA) · all RIPK4 data types