Across TCGA cell cohorts, RIPK4 mutation is significantly associated with the RNA expression of many other genes, with 346 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RIPK4-associated genes across cancer lineages are DNAH8, KLHL40, and PLPBP. Each is linked with RIPK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both RIPK4-to-partner and partner-to-RIPK4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIPK4→partner) and Y-score (partner→RIPK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	DNAH8 →	+0.318	+3.679	.001	.005	3	2
SOFT_TISSUE	KLHL40 →	+1.172	+3.597	.002	.006	3	2
LARGE_INTESTINE	PLPBP →	+0.568	+2.459	.006	.006	3	2
LARGE_INTESTINE	ZCCHC24 →	+0.716	+3.169	.004	.006	3	2
LARGE_INTESTINE	TADA2A →	+0.443	+2.364	.001	<.001	3	2
LARGE_INTESTINE	IPO5 →	+0.478	+3.321	.008	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 346 associations by consensus.

Exploration

RIPK4 survival (RNA) · tumor vs normal (RNA) · all RIPK4 data types