RIPK3

Across TCGA patient cohorts, RIPK3 protein abundance is significantly associated with the RNA expression of many other genes, with 15,439 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible RIPK3-associated genes across cancer lineages are JCHAIN, CCRL2, and INPP5D. Each is linked with RIPK3 in more than 5 cancer types. Because this analysis shows association rather than direction, both RIPK3-to-partner and partner-to-RIPK3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RIPK3 versus JCHAIN in GBM, with a Pearson correlation of 0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIPK3→partner) and Y-score (partner→RIPK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	JCHAIN →	+1.897	+0.506	<.001	<.001	3	6
GBM	CCRL2 →	+0.888	+0.497	<.001	<.001	3	6
LSCC	INPP5D →	+0.833	+0.317	<.001	<.001	3	6
GBM	PTAFR →	+1.004	+0.488	<.001	<.001	3	6
GBM	SPN →	+0.772	+0.619	<.001	<.001	3	6
COAD	NELFCD →	-0.791	-0.246	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,439 associations by consensus.

RIPK3 vs JCHAIN — GBM

Explore this scatter interactively →