RIPK3

Across TCGA patient cohorts, RIPK3 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RIPK3-associated genes across cancer lineages are EGFR, eIF4G, and A-Raf_pS299. Each is linked with RIPK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RIPK3-to-partner and partner-to-RIPK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by RIPK3-low versus RIPK3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIPK3→partner) and Y-score (partner→RIPK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.155	-1.678	.011	.023	3	2
UCEC	eIF4G →	+0.275	+2.321	.021	.033	3	2
UCEC	A-Raf_pS299 →	-0.094	-2.321	.039	.033	3	2
UCEC	MSH2 →	-0.364	-2.674	<.001	.005	3	2
UCEC	14-3-3_beta →	-0.117	-2.074	.002	.005	3	1
UCEC	eIF4E →	+0.204	+2.700	.011	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

EGFR by RIPK3 expression — UCEC

Explore this box plot interactively →