RIPK3

Across TCGA cell cohorts, RIPK3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,288 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible RIPK3-associated GO terms across cancer lineages are Regulation of CD8-positive, alpha-beta T cell extravasation, Multivesicular body assembly, and Viral budding via host ESCRT complex. Each is linked with RIPK3 in more than 14 cancer types. Because this analysis shows association rather than direction, both RIPK3-to-partner and partner-to-RIPK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of CD8-positive, alpha-beta T cell extravasation grouped by RIPK3-low versus RIPK3-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RIPK3→partner) and Y-score (partner→RIPK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of CD8-positive, alpha-beta T cell extravasation →	-0.485	-0.923	<.001	<.001	3	15
LUNG_NSCLC_LUSC	Multivesicular body assembly →	+0.080	+1.027	.005	.002	3	11
PANCREAS	Viral budding via host ESCRT complex →	+0.071	+1.418	.004	.002	3	11
PANCREAS	Negative regulation of actin filament polymerization →	+0.228	+1.870	<.001	<.001	3	11
PANCREAS	Regulation of actin polymerization or depolymerization →	+0.090	+1.742	<.001	<.001	3	10
STOMACH	Epidermal cell differentiation →	+0.105	+2.017	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,288 associations by consensus.

Regulation of CD8-positive, alpha-beta T cell extravasation by RIPK3 expression — LUNG_SCLC

Explore this box plot interactively →