RIPK3

Across TCGA cell cohorts, RIPK3 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RIPK3-associated genes across cancer lineages are FAM170A, OR4F5, and HCRTR2. Each is linked with RIPK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RIPK3-to-partner and partner-to-RIPK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM170A grouped by RIPK3-low versus RIPK3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIPK3→partner) and Y-score (partner→RIPK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM170A →	+0.125	+4.070	<.001	.003	3	1
LARGE_INTESTINE	OR4F5 →	+0.024	+3.345	<.001	.007	3	1
BLOOD_Leukemia	HCRTR2 →	+0.010	+4.551	.007	.004	3	1
BLOOD_Leukemia	CCKAR →	+0.038	+4.409	<.001	.005	3	1
BLOOD_Leukemia	TMEM132C →	+1.146	+4.551	<.001	.004	3	1
BLOOD_Leukemia	MC2R →	+0.004	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

FAM170A by RIPK3 expression — LARGE_INTESTINE

Explore this box plot interactively →