RIPK2

Across TCGA patient cohorts, RIPK2 mutation is significantly associated with the RNA expression of many other genes, with 759 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RIPK2-associated genes across cancer lineages are GAGE13, RNU6-753P, and OR4H12P. Each is linked with RIPK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RIPK2-to-partner and partner-to-RIPK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAGE13 grouped by RIPK2-low versus RIPK2-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIPK2→partner) and Y-score (partner→RIPK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GAGE13 →	+0.587	+6.936	<.001	<.001	3	2
UCEC	RNU6-753P →	+0.226	+3.812	<.001	.008	3	2
SKCM	OR4H12P →	+0.052	+6.810	<.001	<.001	3	2
SKCM	SSXP9 →	+0.691	+4.594	<.001	.008	3	2
LUAD	RNU6-374P →	+0.508	+7.930	<.001	.008	3	1
LUAD	RN7SKP223 →	+0.456	+7.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 759 associations by consensus.

GAGE13 by RIPK2 expression — HNSC

Explore this box plot interactively →