RIPK2

Across TCGA patient cohorts, RIPK2 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RIPK2-associated genes across cancer lineages are FASN, G6PD, and INPP4B. Each is linked with RIPK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RIPK2-to-partner and partner-to-RIPK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by RIPK2-low versus RIPK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIPK2→partner) and Y-score (partner→RIPK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.424	+2.321	.009	.006	3	2
UCEC	G6PD →	+0.290	+1.807	.030	.027	3	1
UCEC	INPP4B →	-0.333	-2.308	.012	.006	3	1
UCEC	mTOR_pS2448 →	-0.162	-2.446	.008	.018	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.436	-2.459	.018	.019	3	1
UCEC	p62 Lck ligand →	+0.321	+2.179	.016	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

FASN by RIPK2 expression — UCEC

Explore this box plot interactively →