RIPK2

Across TCGA cell cohorts, RIPK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,421 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RIPK2-associated GO terms across cancer lineages are Toll-like receptor 2 signaling pathway, Blastocyst growth, and Regulation of protein K63-linked ubiquitination. Each is linked with RIPK2 in more than 18 cancer types. Because this analysis shows association rather than direction, both RIPK2-to-partner and partner-to-RIPK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Toll-like receptor 2 signaling pathway grouped by RIPK2-low versus RIPK2-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RIPK2→partner) and Y-score (partner→RIPK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Toll-like receptor 2 signaling pathway →	+0.257	+1.062	<.001	.003	3	19
LUNG_SCLC	Blastocyst growth →	+0.206	+1.572	<.001	<.001	3	18
LUNG_NSCLC_LUSC	Regulation of protein K63-linked ubiquitination →	+0.144	+1.044	.007	.003	3	15
LUNG_SCLC	Nucleotide-binding oligomerization domain containing 1 signaling pathway →	+0.579	+1.416	.002	.001	3	14
LIVER	Positive regulation of protein polyubiquitination →	+0.187	+1.679	<.001	<.001	3	12
BONE	Response to muramyl dipeptide →	+0.119	+0.903	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,421 associations by consensus.

Toll-like receptor 2 signaling pathway by RIPK2 expression — LIVER

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