RIPK2

Across TCGA cell cohorts, RIPK2 mutation is significantly associated with the RNA expression of many other genes, with 233 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RIPK2-associated genes across cancer lineages are L3MBTL2, POLR3H, and RLN2. Each is linked with RIPK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RIPK2-to-partner and partner-to-RIPK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, L3MBTL2 grouped by RIPK2-low versus RIPK2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIPK2→partner) and Y-score (partner→RIPK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	L3MBTL2 →	+0.586	+3.212	.005	.006	3	1
LARGE_INTESTINE	POLR3H →	+0.785	+3.212	.001	.006	3	1
LARGE_INTESTINE	RLN2 →	+0.770	+3.212	.007	.006	3	1
LARGE_INTESTINE	RAD51C →	+0.983	+3.299	.001	.004	3	1
LARGE_INTESTINE	MED31 →	+0.704	+3.212	.002	.006	3	1
LARGE_INTESTINE	EPM2A →	+0.562	+3.212	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 233 associations by consensus.

L3MBTL2 by RIPK2 expression — LARGE_INTESTINE

Explore this box plot interactively →