RIPK1

Across TCGA patient cohorts, RIPK1 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RIPK1-associated genes across cancer lineages are 14-3-3_beta, Src_pY416, and Bax. Each is linked with RIPK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RIPK1-to-partner and partner-to-RIPK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by RIPK1-low versus RIPK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIPK1→partner) and Y-score (partner→RIPK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.073	-3.143	.024	.018	3	2
UCEC	Src_pY416 →	-0.173	-1.446	.027	.012	3	2
UCEC	Bax →	+0.192	+1.857	.013	.004	3	2
UCEC	eEF2 →	+0.409	+2.415	<.001	.002	3	1
UCEC	EGFR_pY1068 →	-0.284	-2.321	<.001	<.001	3	1
UCEC	eIF4E →	+0.204	+2.700	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

14-3-3_beta by RIPK1 expression — UCEC

Explore this box plot interactively →