RIPK1

Across TCGA cell cohorts, RIPK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,869 significant associations in total. BONE shows the largest number of these associations.

The most reproducible RIPK1-associated GO terms across cancer lineages are Positive regulation of interleukin-6-mediated signaling pathway, Positive regulation of post-transcriptional gene silencing by RNA, and Positive regulation of miRNA-mediated gene silencing. Each is linked with RIPK1 in more than 18 cancer types. Because this analysis shows association rather than direction, both RIPK1-to-partner and partner-to-RIPK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of interleukin-6-mediated signaling pathway grouped by RIPK1-low versus RIPK1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RIPK1→partner) and Y-score (partner→RIPK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of interleukin-6-mediated signaling pathway →	+1.282	+0.860	<.001	<.001	3	19
STOMACH	Positive regulation of post-transcriptional gene silencing by RNA →	+0.132	+0.925	.001	<.001	3	18
STOMACH	Positive regulation of miRNA-mediated gene silencing →	+0.132	+0.925	.001	<.001	3	18
STOMACH	Positive regulation of post-transcriptional gene silencing →	+0.132	+0.925	.001	<.001	3	18
BONE	Regulation of interleukin-6-mediated signaling pathway →	+0.365	+1.014	<.001	<.001	3	17
LIVER	Positive regulation of miRNA processing →	+0.181	+1.185	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,869 associations by consensus.

Positive regulation of interleukin-6-mediated signaling pathway by RIPK1 expression — BONE

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