RIOX2

Across TCGA patient cohorts, RIOX2 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RIOX2-associated genes across cancer lineages are 14-3-3_beta, Rictor_pT1135, and EGFR_pY1068. Each is linked with RIOX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RIOX2-to-partner and partner-to-RIOX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by RIOX2-low versus RIOX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIOX2→partner) and Y-score (partner→RIOX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.097	-1.745	.005	.013	3	2
UCEC	Rictor_pT1135 →	-0.087	-1.906	.014	.015	3	2
UCEC	EGFR_pY1068 →	-0.245	-1.906	.004	.015	3	1
UCEC	EGFR →	-0.190	-1.807	<.001	.025	3	1
UCEC	FASN →	+0.328	+2.222	.016	.010	3	1
UCEC	Gab2 →	+0.310	+3.169	.012	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

14-3-3_beta by RIOX2 expression — UCEC

Explore this box plot interactively →