RIOX2

Across TCGA cell cohorts, RIOX2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,859 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RIOX2-associated GO terms across cancer lineages are tRNA wobble guanine modification, Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), and Mitochondrial RNA metabolic process. Each is linked with RIOX2 in more than 14 cancer types. Because this analysis shows association rather than direction, both RIOX2-to-partner and partner-to-RIOX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, tRNA wobble guanine modification grouped by RIOX2-low versus RIOX2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RIOX2→partner) and Y-score (partner→RIOX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	tRNA wobble guanine modification →	+0.150	+1.347	<.001	.002	2	15
PANCREAS	Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.070	+0.442	.005	.001	3	10
STOMACH	Mitochondrial RNA metabolic process →	+0.083	+0.665	.004	.007	2	11
BLOOD_Lymphoma	Positive regulation of rRNA processing →	+0.134	+1.063	<.001	.001	3	10
LUNG_SCLC	Maturation of SSU-rRNA →	+0.124	+1.554	<.001	<.001	3	10
PANCREAS	rRNA metabolic process →	+0.089	+0.577	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,859 associations by consensus.

tRNA wobble guanine modification by RIOX2 expression — LUNG_SCLC

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