RIOX1

Across TCGA patient cohorts, RIOX1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RIOX1-associated genes across cancer lineages are Heregulin, IGFBP2, and INPP4B. Each is linked with RIOX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RIOX1-to-partner and partner-to-RIOX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heregulin grouped by RIOX1-low versus RIOX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIOX1→partner) and Y-score (partner→RIOX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Heregulin →	-0.131	-1.986	.005	.029	3	1
UCEC	IGFBP2 →	-0.611	-2.321	.014	.033	3	1
UCEC	INPP4B →	-0.257	-2.459	.038	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.137	-1.664	.033	.023	3	1
UCEC	JNK2 →	+0.202	+2.087	.007	.005	3	1
UCEC	Ku80 →	+0.245	+1.691	.006	.014	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Heregulin by RIOX1 expression — UCEC

Explore this box plot interactively →