RIOK3

Across TCGA patient cohorts, RIOK3 mutation is significantly associated with the RNA expression of many other genes, with 2,629 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RIOK3-associated genes across cancer lineages are RNU6-1213P, IGHD2-15, and IGHD3-22. Each is linked with RIOK3 in more than 2 cancer types. Because this analysis shows association rather than direction, both RIOK3-to-partner and partner-to-RIOK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1213P grouped by RIOK3-low versus RIOK3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIOK3→partner) and Y-score (partner→RIOK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-1213P →	+0.133	+3.002	<.001	.006	3	3
BLCA	IGHD2-15 →	+1.779	+5.341	<.001	<.001	3	2
UCEC	IGHD3-22 →	+1.322	+2.051	.001	<.001	3	2
UCEC	RN7SKP286 →	+0.049	+4.186	<.001	<.001	3	2
UCEC	PPIL2 →	+0.350	+2.885	.002	<.001	3	1
UCEC	MAPK1 →	+0.625	+3.939	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,629 associations by consensus.

RNU6-1213P by RIOK3 expression — UCEC

Explore this box plot interactively →